In vitro delayed response to dihydroartemisinin of malaria parasites infecting sickle cell erythocytes.

ABSTRACT:

Background

Decreased efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria has been previously reported in patients with sickle cell disease (SCD). The main purpose of this study was to investigate the in vitro susceptibility of isolates to dihydro-artemisinin (DHA) to provide a hypothesis to explain this treatment failure.

Methods

Isolates were collected from patients attending health centres in Abidjan with uncomplicated P. falciparum malaria. The haemoglobin type has been identified and in vitro drug sensitivity tests were conducted with the ring stage assay and maturation inhibition assay.

Results

134 isolates were obtained. Parasitaemia and haemoglobin levels at inclusion were lower in patients with haemoglobin HbSS and HbSC th

SUBMITTER: Gnondjui AA 

PROVIDER: S-EPMC10768257 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature