Evaluation of the causal effects of blood metabolites on irritable bowel syndrome: Mendelian randomization.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, discomfort, and changes in bowel habits. The mechanism underlying IBS remains unclear, and little evidence exists for clarifying the causal relationship between blood metabolites and IBS.

Methods

We conducted a Mendelian randomization (MR) study using two samples. Exposure data for 7824 Europeans were extracted from a genome-wide association study (GWAS) on metabolite levels. The IBS GWAS data from the GWAS database were used for the initial analysis. The primary analysis of causal relationships was conducted using inverse-variance weighting (IVW) with MR-Egger and weighted medians as supplementary analyses. Sensitivity analyses were performed using a c

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC10768268 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature