Tryptophan metabolites and gut microbiota play an important role in pediatric migraine diagnosis.

ABSTRACT:

Background

The pathogenesis of pediatric migraine remains unclear and presents challenges in diagnosis. Recently, growing evidence has indicated that the gut microbiota can exert modulatory functions at the gut-brain axis by directly or indirectly regulating tryptophan metabolism. Consequently, we aimed to elucidate the potential association among gut microbiota, tryptophan metabolism, and pediatric migraine while also identifying diagnostic biomarkers for pediatric migraine.

Methods

The gut microbiota composition of 33 migraine children and 42 healthy children, aged less than ten years, from the GMrepo database, was analyzed using the Shannon index, Simpson index, principal coordinates analysis, and Wilcoxon rank-sum test. Microbial diagnostic biomarkers were identified usi

SUBMITTER: Liu J 

PROVIDER: S-EPMC10768287 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature