Genomic surveillance of Anopheles mosquitoes on the Bijagos Archipelago using custom targeted amplicon sequencing identifies mutations associated with insecticide resistance.

ABSTRACT:

Background

Insecticide resistance is reducing the efficacy of vector control interventions, consequently threatening efforts to control vector-borne diseases, including malaria. Investigating the prevalence of molecular markers of resistance is a useful tool for monitoring the spread of insecticide resistance in disease vectors. The Bijagós Archipelago (Bijagós) in Guinea-Bissau is a region of stable malaria transmission where insecticide-treated nets are the mainstay for malaria control. However, the prevalence of molecular markers of insecticide resistance in malaria vectors is not well understood.

Methods

A total of 214 Anopheles mosquitoes were analysed from 13 islands across the Bijagós. These mosquitoes were collected using CDC light traps in November 2019, during the

SUBMITTER: Moss S 

PROVIDER: S-EPMC10768400 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature