High-expressed ACAT2 predicted the poor prognosis of platinum-resistant epithelial ovarian cancer.

ABSTRACT:

Background

Acetyl-CoA acetyltransferase 2 (ACAT2) is a lipid metabolism enzyme and rarely was researched in epithelial ovarian cancer (EOC).

Methods

ACAT2 expressions were confirmed in two pairs of cell lines (A2780 and A2780/DDP, OVCAR8 and OVCAR8/DDP) from Gene Expression Omnibus database by bioinformatics analysis, and in A2780 and A2780/DDP cell lines by quantitative real-time polymerase chain reaction and western blotting. Tissue samples were stained by immunohistochemistry and scored for ACAT2 expression. The relationships between ACAT2 expression and clinicopathological characteristics were analyzed by χ² test. The prognosis of ACAT2 was analyzed by the log-rank tests and Cox regression models.

Results

ACAT2 was remarkably upregulated in the above dr

SUBMITTER: Wang J 

PROVIDER: S-EPMC10768435 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature