Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls.

ABSTRACT:

Objective

Myalgic Encephalomyelitis (ME; sometimes referred to as Chronic Fatigue Syndrome) is a chronic disease without laboratory test, detailed aetiological understanding or effective therapy. Its symptoms are diverse, but it is distinguished from other fatiguing illnesses by the experience of post-exertional malaise, the worsening of symptoms even after minor physical or mental exertion. Its frequent onset after infection suggests autoimmune involvement or that it arises from abnormal T-cell activation.

Results

To test this hypothesis, we sequenced the genomic loci of α/δ, β and γ T-cell receptors (TCR) from 40 human blood samples from each of four groups: severely affected people with ME; mildly or moderately affected people with ME; people diagnosed with Multiple Scler

SUBMITTER: Dibble JJ 

PROVIDER: S-EPMC10768444 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature