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ABSTRACT: Background
Translation into clinical practice for use of intravenous thrombolysis (IVT) for the management of ischemic stroke remains a challenge especially across low- and middle-income countries, with regional inconsistencies in its rate. This study aimed at identifying factors that influenced the provision of IVT and the variation in its rates in Malaysia.Methods
A multiple case study underpinning the Tailored Implementation for Chronic Diseases framework was carried out in three public hospitals with differing rates of IVT using a multiple method design. Twenty-five in-depth interviews and 12 focus groups discussions were conducted among 89 healthcare providers, along with a survey on hospital resources and a medical records review to identify reasons for not receiving IVT. Qualitative data were analysed using reflective thematic method, before triangulated with quantitative findings.Results
Of five factors identified, three factors that distinctively influenced the variation of IVT across the hospitals were: 1) leadership through quality stroke champions, 2) team cohesiveness which entailed team dynamics and its degree of alignment and, 3) facilitative work process which included workflow simplification and familiarity with IVT. Two other factors that were consistently identified as barriers in these hospitals included patient factors which largely encompassed delayed presentation, and resource constraints. About 50.0 - 67.6% of ischemic stroke patients missed the opportunity to receive IVT due to delayed presentation.Conclusions
In addition to the global effort to explore sustainable measures to improve patients' emergency response for stroke, attempts to improve the provision of IVT for stroke care should also consider the inclusion of interventions targeting on health systems perspectives such as promoting quality leadership, team cohesiveness and workflow optimisation.
SUBMITTER: Hwong WY
PROVIDER: S-EPMC10768456 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Hwong Wen Yea WY Ng Sock Wen SW Tong Seng Fah SF Ab Rahman Norazida N Law Wan Chung WC Wong Sing Keat SK Puvanarajah Santhi Datuk SD Mohd Norzi Aisyah A Lian Fiona Suling FS Sivasampu Sheamini S
BMC health services research 20240105 1
<h4>Background</h4>Translation into clinical practice for use of intravenous thrombolysis (IVT) for the management of ischemic stroke remains a challenge especially across low- and middle-income countries, with regional inconsistencies in its rate. This study aimed at identifying factors that influenced the provision of IVT and the variation in its rates in Malaysia.<h4>Methods</h4>A multiple case study underpinning the Tailored Implementation for Chronic Diseases framework was carried out in th ...[more]