COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors.

ABSTRACT:

Background

The absence of expression of the Y-chromosome linked testis-determining gene SRY in early supporting gonadal cells (ESGC) leads bipotential gonads into ovarian development. However, genetic variants in NR2F2, encoding three isoforms of the transcription factor COUP-TFII, represent a novel cause of SRY-negative 46,XX testicular/ovotesticular differences of sex development (T/OT-DSD). Thus, we hypothesized that COUP-TFII is part of the ovarian developmental network. COUP-TFII is known to be expressed in interstitial/mesenchymal cells giving rise to steroidogenic cells in fetal gonads, however its expression and function in ESGCs have yet to be explored.

Results

By differentiating induced pluripotent stem cells into bipotential gonad-like cells in vitro and by analyz

SUBMITTER: Ferreira LGA 

PROVIDER: S-EPMC10768475 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature