Mendelian randomization provides evidence for a causal effect of serum insulin-like growth factor family concentration on risk of atrial fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF) is one of the most common persistent arrhythmias among adult cardiovascular diseases. It is important to identify potential risk factors for AF. Members of the insulin-like growth factor (IGF) family exert a variety of effects on various cell types in the context of the pathogenesis of cardiovascular diseases, and previous population-based studies indicate associations between IGF family members and AF. However, the causal effects of IGF family members in AF have not been evaluated.

Aim

In the current study two-sample Mendelian Randomization (MR) was used to assess genetic relationships between IGF family members and AF.

Methods

MR was performed based on genome-wide association study (GWAS) datasets, and concentration levels of 14 I

SUBMITTER: Lin S 

PROVIDER: S-EPMC10768518 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature