Identification of prognostic risk score of disulfidptosis-related genes and molecular subtypes in glioma.

ABSTRACT:

Background

Programmed cell death is closely related to glioma. As a novel kind of cell death, the mechanism of disulfidptosis in glioma remains unclear. Therefore, it is of great importance to study the role of disulfidptosis-related genes (DRGs) in glioma.

Methods

We first investigated the genetic and transcriptional alterations of 15 DRGs. Two consensus cluster analyses were used to evaluate the association between DRGs and glioma subtypes. In addition, we constructed prognostic DRG risk scores to predict overall survival (OS) in glioma patients. Furthermore, we developed a nomogram to enhance the clinical utility of the DRG risk score. Finally, the expression levels of DRGs were verified by immunohistochemistry (IHC) staining.

Results

Most DRGs (14/15) were dysregu

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC10768521 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature