Different impulse control disorder evolution patterns and white matter microstructural damage in the progression of Parkinson's disease.

ABSTRACT:

Background

The course of impulse control disorders (ICD) varies in the early stage of Parkinson's disease (PD).

Aim

We aimed to delineate the association between the evolution pattern of ICD and the progression of PD.

Methods

A total of 321 de novo PD patients from the Parkinson's Progression Markers Initiative database were included. Patients were followed up for a mean of 6.8 years and were classified into different groups according to the evolution patterns of ICD. Disease progression was compared among groups using survival analysis, in which the endpoint was defined as progression to Hoehn and Yahr stage 3 or higher for motor progression and progression to mild cognitive impairment for cognitive decline. In the fourth year of follow-up, four types of ICD e

SUBMITTER: Hu L 

PROVIDER: S-EPMC10768538 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature