Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis.

ABSTRACT:

Purpose

Non-infectious uveitis is a complex disease characterized by intraocular inflammation of the uveal area and the leading cause of vision impairment and blindness in young people globally. However, what triggers inflammation and contributes to its recurrence remains unclear. The complement system has been linked to various immunological and inflammatory conditions. In the present study, we have systematically evaluated the role of the alternative complement pathway in the pathogenesis of non-infectious uveitis.

Methodology

Quantitative PCR was done in the peripheral leukocytes to study the expression of genes and regulatory miRNA in both anterior and posterior uveitis (n=28 in each category). Multiplex ELISA was performed to measure alternative pathway complement compo

SUBMITTER: Kulshrestha P 

PROVIDER: S-EPMC10768558 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature