Effect of Propranolol on Motor Cortex Excitability in Essential Tremor: An Exploratory Study.

ABSTRACT:

Background

Essential tremor, the world's most prevalent movement disorder, lacks a clear understanding of its pathophysiology. Propranolol, a non-specific beta-blocker capable of crossing the blood-brain barrier, is a primary choice for essential tremor treatment. While its tremor-reducing effects are generally attributed to peripheral actions, various uses hint at central adrenergic effects. Nevertheless, propranolol's precise impact on the central nervous system in essential tremor subjects remains unexplored.

Methods

In this study, we employed transcranial magnetic stimulation to assess the influence of propranolol on the excitability of the primary motor cortex (M1) in patients with essential tremor, compared to an age- and sex-matched control group. Cortical excitabilit

SUBMITTER: Miguel-Puga A 

PROVIDER: S-EPMC10768567 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature