Quercetin alleviates PM_2.5-induced chronic lung injury in mice by targeting ferroptosis.

ABSTRACT:

Background

PM_2.5 is a well-known harmful air pollutant that can lead to acute exacerbation and aggravation of respiratory diseases. Although ferroptosis is involves in the pathological process of pulmonary disease, the potential mechanism of ferroptosis in PM_2.5-caused lung inflammation and fibrosis need to be further clarified. Quercetin is a phenolic compound that can inhibit ferroptosis in various diseases. Hence, this study explores the role of ferroptosis in lung injury induced by PM_2.5 in order to further elucidate the beneficial effect of quercetin and its underlying mechanism.

Methods

C57BL/6J mice were treated with either saline or PM_2.5 by intratracheal instillation 20 times (once every two days). Additionally, PM_2.5

SUBMITTER: Ding S 

PROVIDER: S-EPMC10768656 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature