Smoking, Corneal Biomechanics, and Glaucoma: Results From Two Large Population-Based Cohorts.

ABSTRACT:

Purpose

Smoking may influence measured IOP through an effect on corneal biomechanics, but it is unclear whether this factor translates into an increased risk for glaucoma. This study aimed to examine the association of cigarette smoking with corneal biomechanical properties and glaucoma-related traits, and to probe potential causal effects using Mendelian randomization (MR).

Methods

Cross-sectional analyses within the UK Biobank (UKB) and Canadian Longitudinal Study on Aging (CLSA) cohorts. Multivariable linear and logistic regression models were used to assess associations of smoking (status, intensity, and duration) with corneal hysteresis (CH), corneal resistance factor, IOP, inner retinal thicknesses, and glaucoma. Two-sample MR analyses were performed.

Results

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SUBMITTER: Stuart KV 

PROVIDER: S-EPMC10768714 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature