Serum sclerostin is associated with recurrent kidney stone formation independent of hypercalciuria.

ABSTRACT:

Background

Kidney stones are frequent in industrialized countries with a lifetime risk of 10 to 15%. A high percentage of individuals experience recurrence. Calcium-containing stones account for more than 80% of kidney stones. Diet, environmental factors, behavior, and genetic variants contribute to the development of kidney stones. Osteocytes excrete the 21 kDa glycoprotein sclerostin, which inhibits bone formation by osteoblasts. Animal data suggests that sclerostin might directly or indirectly regulate calcium excretion via the kidney. As hypercalciuria is one of the most relevant risk factors for kidney stones, sclerostin might possess pathogenic relevance in nephrolithiasis.

Methods

We performed a prospective cross-sectional observational controlled study in 150 recurre

SUBMITTER: Rodriguez D 

PROVIDER: S-EPMC10768761 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature