Early growth response 1 as a podocyte injury marker in human glomerular diseases.

ABSTRACT:

Background

In human glomerular diseases, visualizing podocyte injury is desirable since podocytes do not regenerate and podocyte injury leads to podocyte loss. Herein, we investigated the utility of immunostaining for early growth response 1 (EGR1), which is expressed in injured podocytes from the early stages of injury in animal experiments, as a podocyte injury marker in human glomerular diseases.

Methods

This study included 102 patients with biopsy-proven glomerular diseases between 2018 and 2021. The proportion of EGR1 expression in podocytes (%EGR1pod) was analyzed in relation to clinical and histopathological features, including glomerular and urinary podocyte-specific markers.

Results

%EGR1pod correlated significantly with the urinary protein:creatinine ratio,

SUBMITTER: Okabe M 

PROVIDER: S-EPMC10768762 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature