Study of the association between serum levels of kynurenine and cardiovascular outcomes and overall mortality in chronic kidney disease.

ABSTRACT:

Background

Kynurenine is a protein-bound uremic toxin. Its circulating levels are increased in chronic kidney disease (CKD). Experimental studies showed that it exerted deleterious cardiovascular effects. We sought to evaluate an association between serum kynurenine levels and adverse fatal or nonfatal cardiovascular events and all-cause mortality in CKD patients.

Methods

The CKD-REIN study is a prospective cohort of people with CKD having an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m². Baseline frozen samples of total and free fractions of kynurenine and tryptophan were measured using a validated liquid chromatography tandem mass spectrometry technique. Cause-specific Cox models were used to estimate hazard ratios (HRs) for each outcome.

Results

Of

SUBMITTER: El Chamieh C 

PROVIDER: S-EPMC10768787 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature