Caudate volume and symptoms of apathy in older adults with multiple sclerosis.

ABSTRACT:

Background

Apathy is common in multiple sclerosis (MS) and neurological disease, but its presence and underlying brain mechanisms in older adults with MS (OAMS) have not been evaluated.

Objective

Examine apathy and its association with caudate nuclei volume in OAMS and controls. We hypothesized that compared to controls, OAMS would demonstrate: a) greater apathy; b) stronger associations between apathy and caudate nuclei volumes.

Methods

OAMS (n = 67, mean age = 64.55 ± 3.89) and controls (n = 74, mean age = 69.04 ± 6.32) underwent brain MRI, cognitive assessment, psychological, and motoric testing. Apathy was assessed through the apathy subscale of the 30-item Geriatric Depression Scale.

Results

OAMS reported greater apathy compared to controls (

SUBMITTER: Cote SE 

PROVIDER: S-EPMC10768811 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature