Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of acute clinical management. While acute, controlled inflammation is important for debris clearance and regeneration after injury, chronic, rampant inflammation plays a significant adverse role in the pathophysiology of secondary brain injury. Immune cell therapies hold unique therapeutic potential for inflammation modulation, due to their active sensing and migration abilities. Macrophages are particularly suited for this task, given the role of macrophages and microglia in the dysregulated inflammatory response after TBI. However, maintaining adoptively transferred macrophages in an anti-inflammatory, wound-healing phenotype against the proinflammatory TBI milieu is essential. To achieve this, we de

SUBMITTER: Kapate N 

PROVIDER: S-EPMC10768983 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature