Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile^☆.

ABSTRACT:

Introduction

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic myocardium. The aim of this study is to determine the effects of CANA in nonischemic myocardium on coronary collateralization, oxidative stress, and other molecular pathways determined by proteomic profiling.

Methods

Yorkshire swine underwent placement of an ameroid constrictor to the left circumflex artery. Two weeks later, pigs received no drug (CON, n = 8) or 300 mg CANA daily (n = 8). Treatment continued for five weeks, followed by tissue harvest of nonischemic myocardium.

Results

CANA was associated with decreased capillary density (p = 0.05) com

SUBMITTER: Sabe SA 

PROVIDER: S-EPMC10769006 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature