Regenerative growth is constrained by brain tumor to ensure proper patterning in Drosophila.

ABSTRACT: Some animals respond to injury by inducing new growth to regenerate the lost structures. This regenerative growth must be carefully controlled and constrained to prevent aberrant growth and to allow correct organization of the regenerating tissue. However, the factors that restrict regenerative growth have not been identified. Using a genetic ablation system in the Drosophila wing imaginal disc, we have identified one mechanism that constrains regenerative growth, impairment of which also leads to erroneous patterning of the final appendage. Regenerating discs with reduced levels of the RNA-regulator Brain tumor (Brat) exhibit enhanced regeneration, but produce adult wings with disrupted margins that are missing extensive tracts of sensory bristles. In these mutants, aberrantly high expres

SUBMITTER: Abidi SNF 

PROVIDER: S-EPMC10769103 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature