Cell surface sculpting using logic-gated protein actuators.

ABSTRACT: Cell differentiation and tissue specialization lead to unique cellular surface landscapes and exacerbated or loss of expression patterns can result in further heterogenicity distinctive of pathological phenotypes^1-3. Immunotherapies and emerging protein therapeutics seek to exploit such differences by engaging cell populations selectively based on their surface markers. Since a single surface antigen rarely defines a specific cell type^4,5, the development of programmable molecular systems that integrate multiple cell surface features to convert on-target inputs to user-defined outputs is highly desirable. Here, we describe an autonomous decision-making protein device driven by proximity-gated protein trans-splicing that allows local generation of an active prot

SUBMITTER: Kofoed C 

PROVIDER: S-EPMC10769198 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature