Zelda is dispensable for <i>Drosophila melanogaster</i> histone gene regulation.

ABSTRACT: To ensure that the embryo can package exponentially increasing amounts of DNA, replication-dependent histones are some of the earliest transcribed genes from the zygotic genome. However, how the histone genes are identified is not known. The pioneer factors Zelda and CLAMP collaborate at a subset of genes to regulate zygotic genome activation in Drosophila melanogaster and target early activated genes to induce transcription. CLAMP also regulates the embryonic histone genes and helps establish the histone locus body, a suite of factors that controls histone mRNA biosynthesis. The relationship between Zelda and CLAMP led us to hypothesize that Zelda helps identify histone genes for early embryonic expression. We found that Zelda targets the histone locus early during embryogenesis, prior to

SUBMITTER: O'Haren T 

PROVIDER: S-EPMC10769256 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature