The intracellular C-terminus confers compartment-specific targeting of voltage-gated Ca²⁺ channels.

ABSTRACT: To achieve the functional polarization that underlies brain computation, neurons sort protein material into distinct compartments. Ion channel composition, for example, differs between axons and dendrites, but the molecular determinants for their polarized trafficking remain obscure. Here, we identify the mechanisms that target voltage-gated Ca²⁺ channels (Ca_Vs) to distinct subcellular compartments. In hippocampal neurons, Ca_V2s trigger neurotransmitter release at the presynaptic active zone, and Ca_V1s localize somatodendritically. After knockout of all three Ca_V2s, expression of Ca_V2.1, but not of Ca_V1.3, restores neurotransmitter release. Chimeric Ca_V1.3 channels with Ca_V2.1 intracellular C

SUBMITTER: Chin M 

PROVIDER: S-EPMC10769351 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature