Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction.

ABSTRACT: Reliable representations of information regarding complex behaviors including social interactions require the coordinated activity of heterogeneous cell types within distributed brain regions. Activity in the medial prefrontal cortex is critical in regulating social behavior, but our understanding of the specific cell types which comprise the social ensemble has been limited by available mouse lines and molecular tagging strategies which rely on the expression of a single marker gene. Here we sought to quantify the heterogeneous neuronal populations which are recruited during social interaction in parallel in a non-biased manner and determine how distinct cell types are differentially active during social interactions. We identify distinct populations of prefrontal neurons activated by soc

SUBMITTER: Walker H 

PROVIDER: S-EPMC10769355 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature