Large scale, simultaneous, chronic neural recordings from multiple brain areas.

ABSTRACT: Understanding how brain activity is related to animal behavior requires measuring multi-area interactions on multiple timescales. However, methods to perform chronic, simultaneous recordings of neural activity from many brain areas are lacking. Here, we introduce a novel approach for independent chronic probe implantation that enables flexible, simultaneous interrogation of neural activity from many brain regions during head restrained or freely moving behavior. The approach, that we called indie (independent dovetail implants for electrophysiology), enables repeated retrieval and reimplantation of probes. The chronic implantation approach can be combined with other modalities such as skull clearing for cortex wide access and optogenetics with optic fibers. Using this approach, we i

SUBMITTER: Melin MD 

PROVIDER: S-EPMC10769364 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature