Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane.

ABSTRACT: Basement membranes are extracellular matrix sheets separating tissue layers and providing mechanical support, and Collagen IV (Col4) is their most abundant protein. Although basement membranes are repaired after damage, little is known about repair, including whether and how damage is detected, what cells repair the damage, and how repair is controlled to avoid fibrosis. Using the intestinal basement membrane of adult Drosophila as a model, we show that after basement membrane damage, there is a sharp increase in enteroblasts transiently expressing Col4, or "matrix mender" cells. Enteroblast-derived Col4 is specifically required for matrix repair. The increase in matrix mender cells requires the mechanosensitive ion channel Piezo, expressed in intestinal stem cells. Matrix menders a

SUBMITTER: Stricker AM 

PROVIDER: S-EPMC10769369 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature