Activated PI3Kδ specifically perturbs mouse Treg homeostasis and function leading to immune dysregulation.

ABSTRACT: Foxp3⁺ regulatory T cells (Treg) are required for maintaining immune tolerance and preventing systemic autoimmunity. PI3Kδ is required for normal Treg development and function. However, the impacts of dysregulated PI3Kδ signaling on Treg function remain incompletely understood. Here, we used a conditional mouse model of activated PI3Kδ syndrome (APDS) to investigate the role of altered PI3Kδ signaling specifically within the Treg compartment. Aged mice expressing a PIK3CD gain-of-function mutation (aPIK3CD) specifically within the Treg compartment exhibited weight loss and evidence for chronic inflammation as demonstrated by increased memory/effector CD4⁺ and CD8⁺ T cells with enhanced IFN-γ secretion, spontaneous germinal center responses and production of

SUBMITTER: Singh AK 

PROVIDER: S-EPMC10769388 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature