Egr1 is a sex-specific regulator of neuronal chromatin, synaptic plasticity, and behaviour.

ABSTRACT: Sex differences are found in brain structure and function across species, and across brain disorders in humans^1-3. The major source of brain sex differences is differential secretion of steroid hormones from the gonads across the lifespan⁴. Specifically, ovarian hormones oestrogens and progesterone are known to dynamically change structure and function of the adult female brain, having a major impact on psychiatric risk^5-7. However, due to limited molecular studies in female rodents⁸, very little is still known about molecular drivers of female-specific brain and behavioural plasticity. Here we show that overexpressing Egr1, a candidate oestrous cycle-dependent transcription factor⁹, induces sex-specific changes in ventral hippocampal

SUBMITTER: Rocks D 

PROVIDER: S-EPMC10769422 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature