Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.

ABSTRACT: The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it is established that the local abundance of specific nutrients defines the metabolic parameters for tumor growth, the factors guiding nutrient availability in tumor compared to normal tissue and blood remain poorly understood. To define these factors in renal cell carcinoma (RCC), we performed quantitative metabolomic and comprehensive lipidomic analyses of tumor interstitial fluid (TIF), adjacent normal kidney interstitial fluid (KIF), and plasma samples collected from patients. TIF nutrient composition closely resembles KIF, suggesting that tissue-specific factors unrelated to the presence of cancer exert a stronger influence on nutr

SUBMITTER: Abbott KL 

PROVIDER: S-EPMC10769456 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature