The Heart of Rett Syndrome: A Quantitative Analysis of Cardiac Repolarization.

ABSTRACT:

Background

Rett syndrome (RTT) is a developmental encephalopathy disorder that is associated with a high incidence of sudden death presumably from cardiorespiratory etiologies. Electrocardiogram (ECG) abnormalities, such as prolonged heart-rate corrected QT (QTc) interval, are markers of cardiac repolarization and are associated with potentially lethal ventricular arrhythmias. This study investigates the cardiac repolarization characteristics of RTT patients, including QTc and T-wave morphology characteristics.

Methods

A retrospective quantitative analysis on 110 RTT patients and 124 age and sex-matched healthy controls was conducted.

Results

RTT patients had longer QTc, more abnormal T-wave morphology, and greater heterogeneity of cardiac repolarization parameters co

SUBMITTER: Collins MP 

PROVIDER: S-EPMC10769616 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature