Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease.

ABSTRACT:

Background

Few drugs have been studied for patients with very early onset inflammatory bowel disease (VEOIBD). This study aimed to evaluate the efficacy and tolerance of thalidomide in children with VEOIBD compared with children with pediatric-onset IBD (pIBD).

Methods

A retrospective cohort study with a control group was conducted. Propensity score 1:1 matching was used to identify control subjects. The treatment persistence; the causes of drug withdrawal; the rate of clinical remission and mucosal healing at 1, 2, and 3 years; and adverse events (AEs) were evaluated in children with VEOIBD treated with thalidomide and compared with children with pIBD.

Results

Thirty-nine courses of treatment with thalidomide in VEOIBD and pIBD patients were compared. The treatment p

SUBMITTER: Bramuzzo M 

PROVIDER: S-EPMC10769807 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature