Co-occurring ripple oscillations facilitate neuronal interactions between cortical locations in humans.

ABSTRACT: How the human cortex integrates ("binds") information encoded by spatially distributed neurons remains largely unknown. One hypothesis suggests that synchronous bursts of high-frequency oscillations ("ripples") contribute to binding by facilitating integration of neuronal firing across different cortical locations. While studies have demonstrated that ripples modulate local activity in the cortex, it is not known whether their co-occurrence coordinates neural firing across larger distances. We tested this hypothesis using local field-potentials and single-unit firing from four 96-channel microelectrode arrays in the supragranular cortex of 3 patients. Neurons in co-rippling locations showed increased short-latency co-firing, prediction of each other's firing, and co-participation in neural

SUBMITTER: Verzhbinsky IA 

PROVIDER: S-EPMC10769862 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature