Association of physical activity with bleeding events and safety in patients with haemophilia A starting emicizumab prophylaxis: an interim analysis of the TSUBASA study.

ABSTRACT:

Introduction

Little information exists on the relationship between bleeding outcomes and physical activity in patients with haemophilia A (PwHA).

Aim

This interim analysis of the TSUBASA study (UMIN-CTR ID: UMIN000037448) evaluated the association of physical activity with bleeding and safety in PwHA starting emicizumab.

Methods

PwHA without factor VIII inhibitors were recruited. Physical activity and bleed data were obtained using an electronic patient-reported outcome application and wearable activity tracker. Adverse events (AEs) were documented.

Results

At data cut-off (31-May-2021), 107 PwHA were enrolled, with a median (range) age of 35 (0-73) years. Physical activity data were obtained for 74 participants. Of these, 47 (63.5%) recorded a total of 396 exe

SUBMITTER: Nogami K 

PROVIDER: S-EPMC10769904 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature