CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization.

ABSTRACT:

Introduction

Leukocyte infiltration is an early event during cardiac remodeling frequently leading to heart failure (HF). Integrins mediate leukocyte infiltration during inflammation. However, the importance of specific integrins in hypertensive cardiac remodeling is still unclear.

Objectives

To elucidate the significance of CD11b in hypertensive cardiac remodeling.

Methods

Angiotensin (Ang II) or deoxycorticosterone acetate (DOCA)-salt was used to induce cardiac remodeling in mice of gene knockout (KO), bone marrow (BM) chimera, and the CD11b neutralizing antibody or agonist leukadherin-1 (LA1) treatment.

Results

Our microarray data showed that integrin subunits Itgam (CD11b) and Itgb2 (CD18) were the most highly upregulated in Ang II-infused hearts. CD11b exp

SUBMITTER: Zhang YL 

PROVIDER: S-EPMC10770112 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature