Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species.

ABSTRACT:

Introduction

Both innate and adaptive immune system undergo evolution from low to high vertebrates. Due to the limitation of conventional approaches in identifying broader spectrum of immune cells and molecules from various vertebrates, it remains unclear how immune molecules evolve among vertebrates.

Objectives

Here, we utilized carry out comparative transcriptome analysis in various immune cells across seven vertebrate species.

Methods

Single-cell RNA sequencing (scRNA-seq).

Results

We uncovered both conserved and species-specific profiling of gene expression in innate and adaptive immunity. Macrophages exhibited highly-diversified genes and developed sophisticated molecular signaling networks along with evolution, indicating effective and versatile functions

SUBMITTER: Jiao A 

PROVIDER: S-EPMC10770119 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature