FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner.

ABSTRACT:

Introduction

Liver fibrosis is a life-threatening pathological anomaly which usually evolves into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic option is readily available. FUN14 domain containing 1 (FUNDC1) is a mitophagy receptor with little information in liver fibrosis.

Objective

This study was designed to examine the role for FUNDC1 in carbon tetrachloride (CCl4)-induced liver injury.

Methods

GEO database analysis and subsequent validation of biological processes including western blot, immunofluorescence, and co-immunoprecipitation were applied to clarify the regulatory role of FUNDC1 on mitophagy and ferroptosis.

Results

Our data revealed elevated FUNDC1 levels in liver tissues of patients with liver fibrotic injury a

SUBMITTER: Bi Y 

PROVIDER: S-EPMC10770120 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature