Functional host-specific adaptation of the intestinal microbiome in hominids.

ABSTRACT: Fine-scale knowledge of the changes in composition and function of the human gut microbiome compared that of our closest relatives is critical for understanding the evolutionary processes underlying its developmental trajectory. To infer taxonomic and functional changes in the gut microbiome across hominids at different timescales, we perform high-resolution metagenomic-based analyzes of the fecal microbiome from over two hundred samples including diverse human populations, as well as wild-living chimpanzees, bonobos, and gorillas. We find human-associated taxa depleted within non-human apes and patterns of host-specific gut microbiota, suggesting the widespread acquisition of novel microbial clades along the evolutionary divergence of hosts. In contrast, we reveal multiple lines of eviden

SUBMITTER: Ruhlemann MC 

PROVIDER: S-EPMC10770139 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature