β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish.
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ABSTRACT:
SUBMITTER: Scatterty KR
PROVIDER: S-EPMC10770314 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish.
Scatterty Kale R KR Hamilton Trevor J TJ
Scientific reports 20240105 1
The β-Carboline FG-7142 is a partial inverse agonist at the benzodiazepine allosteric site on the GABA-A receptor that induces anxiogenic, proconvulsant, and appetite-reducing effects in many species, including humans. Seizure-kindling effects have been well studied, however anxiogenic properties are relatively unexplored. This study aimed to investigate concentration-dependent effects of FG-7142 on anxiety-like behaviour and fear responses in zebrafish (Danio rerio) using the open-field test (O ...[more]
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