Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199.

ABSTRACT: Adhesion molecules play essential roles in the homeostatic regulation and malignant transformation of hematopoietic cells. The dysregulated expression of adhesion molecules in leukemic cells accelerates disease progression and the development of drug resistance. Thus, targeting adhesion molecules represents an attractive anti-leukemic therapeutic strategy. In this study, we investigated the prognostic role and functional significance of cytohesin-1 (CYTH1) in acute myeloid leukemia (AML). Analysis of AML patient data from the GEPIA and BloodSpot databases revealed that CYTH1 was significantly overexpressed in AML and independently correlated with prognosis. Functional assays using AML cell lines and an AML xenograft mouse model confirmed that CYTH1 depletion significantly inhibited the adh

SUBMITTER: Ren WX 

PROVIDER: S-EPMC10770340 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature