Diverse bacteria elicit distinct neutrophil responses in a physiologically relevant model of infection.

ABSTRACT: An efficient neutrophil response is critical for fighting bacterial infections, which remain a significant global health concern; therefore, modulating neutrophil function could be an effective therapeutic approach. While we have a general understanding of how neutrophils respond to bacteria, how neutrophil function differs in response to diverse bacterial infections remains unclear. Here, we use a microfluidic infection-on-a-chip device to investigate the neutrophil response to four bacterial species: Pseudomonas aeruginosa, Salmonella enterica, Listeria monocytogenes, and Staphylococcus aureus. We find enhanced neutrophil extravasation to L. monocytogenes, a limited overall response to S. aureus, and identify IL-6 as universally important for neu

SUBMITTER: Richardson IM 

PROVIDER: S-EPMC10770534 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature