CardiOmics signatures reveal therapeutically actionable targets and drugs for cardiovascular diseases.

ABSTRACT: Cardiovascular diseases are the leading cause of death worldwide, with heart failure being a complex condition that affects millions of individuals. Single-nucleus RNA sequencing has recently emerged as a powerful tool for unraveling the molecular mechanisms behind cardiovascular diseases. This cutting-edge technology enables the identification of molecular signatures, intracellular networks, and spatial relationships among cardiac cells, including cardiomyocytes, mast cells, lymphocytes, macrophages, lymphatic endothelial cells, endocardial cells, endothelial cells, epicardial cells, adipocytes, fibroblasts, neuronal cells, pericytes, and vascular smooth muscle cells. Despite these advancements, the discovery of essential therapeutic targets and drugs for precision cardiology remains a ch

SUBMITTER: Ramos-Medina MJ 

PROVIDER: S-EPMC10770621 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature