Grey-matter structure in cortical and limbic regions correlates with general cognitive ability in old age.

ABSTRACT: According to the maintenance hypothesis (Nyberg et al., 2012), structural integrity of the brain's grey matter helps to preserve cognitive functioning into old age. A corollary of this hypothesis that can be tested in cross-sectional data is that grey-matter structural integrity and general cognitive ability are positively associated in old age. Building on Köhncke et al. (2021), who found that region-specific latent factors of grey-matter integrity are positively associated with episodic memory ability among older adults, we examine associations between general factors of grey-matter integrity and a general factor of cognitive ability in a cross-sectional sample of 1466 participants aged 60-88 years, 319 of whom contributed imaging data. Indicator variables based on T1-weighted images (vo

SUBMITTER: Kohncke Y 

PROVIDER: S-EPMC10770753 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature