Causal association of immune cells and polycystic ovarian syndrome: a Mendelian randomization study.

ABSTRACT:

Background

Polycystic ovarian syndrome (PCOS) is a common reproductive disorder that affects a considerable number of women worldwide. It is accompanied by irregular menstruation, hyperandrogenism, metabolic abnormalities, reproductive disorders and other clinical symptoms, which seriously endangers women's physical and mental health. The etiology and pathogenesis of PCOS are not completely clear, but it is hypothesized that immune system may play a key role in it. However, previous studies investigating the connection between immune cells and PCOS have produced conflicting results.

Methods

Mendelian randomization (MR) is a powerful study design that uses genetic variants as instrumental variables to enable examination of the causal effect of an exposure on an outcome in obs

SUBMITTER: Aru N 

PROVIDER: S-EPMC10770856 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature