HELIOS-expressing human CD8 T cells exhibit limited effector functions.

ABSTRACT:

Introduction

The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells. However, information on human HELIOS⁺ CD8 T cells is limited and conflicting.

Methods

In this study, we characterized by flow cytometry and transcriptomic analyses human HELIOS⁺ CD8 T cells.

Results

These T cells primarily consist of memory cells and constitute approximately 21% of blood CD8 T cells. In comparison with memory HELIOS^- T-BET^high CD8 T cells that displayed robust effector functions, the memory HELIOS⁺ T-BET^high CD8 T cells produce lower amounts of IFN-γ and TNF-α and have a lower cytotoxic potential. We won

SUBMITTER: Neyens D 

PROVIDER: S-EPMC10770868 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature