Muller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma.

ABSTRACT:

Background

Glaucoma, a progressive neurodegenerative disease, is a leading cause of irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia (MG) in the context of retinal ganglion cell (RGC) death, particularly focusing on the influence of peripheral MG sensitivity to high pressure (HP).

Methods

Co-cultures of porcine RGCs with MG were isolated from both the central and peripheral regions of pig retinas and subjected to both normal and HP conditions. Mass spectrometry analysis of the MG-conditioned medium was conducted to identify the proteins released by MG under all conditions.

Results

Peripheral MG were found to secrete a higher quantity of neuroprotective factors, effectively promoting RGC survival under normal physiologic

SUBMITTER: Pereiro X 

PROVIDER: S-EPMC10770903 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature