Do neutrophil extracellular traps implicate in atheromatous plaques from carotid endarterectomy? Re-analyzes of cDNA microarray data by surgeons.

ABSTRACT:

Background

Carotid artery stenosis is the cause of 15% of strokes. Neutrophil extracellular traps (NETs) and peptidyl arginine deiminase 4 (PAD4) are believed to be involved in thrombosis. This pilot study described the differential expression profile of NETs between atheromatous plaques and surrounding tissues.

Methods

Microarray datasets of carotid plaques were obtained from Gene Expression Omnibus. The normalized data were processed into comma-separated value matrix files using spreadsheet software. Analyzes of microarray data were conducted using integrated differential expression and pathway analysis.

Result

The clustering results illustrated that the classifications of plaque and control had reasonable biological validity. Pathway analysis revealed the relevance

SUBMITTER: Takahira R 

PROVIDER: S-EPMC10770953 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature