Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas.

ABSTRACT:

Background

The placenta is vital for fetal development and its contributions to various developmental issues, such as pregnancy complications, fetal growth restriction, and maternal exposure, have been extensively studied in mice. The placenta forms mainly from fetal tissue and therefore has the same biological sex as the fetus it supports. Extensive research has delved into the placenta's involvement in pregnancy complications and future offspring development, with a notable emphasis on exploring sex-specific disparities. However, despite these investigations, sex-based disparities in epigenetic (e.g., DNA methylation) and transcriptomic features of the late-gestation mouse placenta remain largely unknown.

Methods

We collected male and female mouse placentas at late gestati

SUBMITTER: Legault LM 

PROVIDER: S-EPMC10770955 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature