Identification of key genes in chronic intermittent hypoxia-induced lung cancer progression based on transcriptome sequencing.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is associated with increased risk of lung cancer mortality. Nevertheless, little is known about the underlying molecular mechanisms. This research aimed to investigate differentially expressed genes (DEGs) and explore their function in Lewis lung carcinoma (LLC)-bearing mice exposed to chronic intermittent hypoxia (CIH) by transcriptome sequencing.

Methods

Lung cancer tissues in LLC-bearing mice exposed to CIH or normoxia were subjected for transcriptome sequencing to examine DEGs. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were employed to explore the function of DEGs. To evaluate the prognostic value of DEGs, the Kaplan-Meier survival analysis in combination with Cox proportional hazard model were app

SUBMITTER: Chen LD 

PROVIDER: S-EPMC10770984 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature